Ruiz-Pesini P, Tomé E, Balaguer L, Romano J, Yllera M
Departamento de Anatomia, Facultad de Veterinaria, Universidad de Santiago, Lugo, Spain.
Brain Res Bull. 1995;37(1):41-6. doi: 10.1016/0361-9230(94)00255-x.
The localization and brain stem projections of neurons innervating the carotid sinus of the dog were studied by horseradish peroxidase histochemistry following microinjection of wheat germ agglutinin-horseradish peroxidase (WGA-HRP) under the adventitia of the carotid sinus. Within the brain stem, labeled afferent fibers and presumptive terminals were found bilaterally in the caudal nucleus tractus solitarius (nTS), the area postrema (AP), and the lateral tegmental field (LTF), reaching the area of the nucleus ambiguus (nA). Sparse labeling was also seen in the ipsilateral spinal trigeminal nucleus (SpV) and lateral cuneatus nucleus (LCn). These findings suggest the existence of multiple pathways by which peripheral baroreceptor inputs may influence central cardiovascular-related neurons. In addition to classically defined relay in the nTS, carotid sinus afferents may also interact more directly with these neurons in other brain stem regions.
通过在狗的颈动脉窦外膜下微量注射小麦胚凝集素-辣根过氧化物酶（WGA-HRP），利用辣根过氧化物酶组织化学方法研究了支配狗颈动脉窦的神经元的定位和脑干投射。在脑干内，双侧在尾侧孤束核（nTS）、最后区（AP）和外侧被盖区（LTF）发现了标记的传入纤维和推定终末，延伸至疑核（nA）区域。在同侧三叉神经脊束核（SpV）和外侧楔束核（LCn）也可见稀疏标记。这些发现提示存在多条外周压力感受器输入可能影响中枢心血管相关神经元的途径。除了在nTS中经典定义的中继外，颈动脉窦传入纤维也可能在其他脑干区域与这些神经元更直接地相互作用。
