Tanaka H, Mizutani H, Okada H, Shimizu M
Department of Dermatology, Mie University Faculty of Medicine, Tsu, Japan.
J Dermatol. 1995 Apr;22(4):262-6. doi: 10.1111/j.1346-8138.1995.tb03383.x.
We report a 29-year-old female OKT4 epitope deficiency patient with primary Sjögren's syndrome and psoriasis vulgaris. Immunological investigations during the prolonged clinical course of her herpes zoster revealed that she has OKT4 epitope deficiency and primary Sjögren's syndrome. She had been treated for psoriasis vulgaris for 17 years without systemic immunosuppressive therapy. Flow cytometric study revealed that her OKT4 deficiency is heterogeneous and excluded interference with the OKT4 epitope by anti OKT4 autoantibodies. The rare coexistence of primary Sjögren's syndrome and psoriasis implicates an immune disturbance due to an unusual phenotype of CD4.
我们报告了一名29岁的女性OKT4表位缺陷患者，她同时患有原发性干燥综合征和寻常型银屑病。在她带状疱疹的长期临床病程中进行的免疫学检查显示，她存在OKT4表位缺陷和原发性干燥综合征。她接受寻常型银屑病治疗已有17年，未进行过全身免疫抑制治疗。流式细胞术研究表明，她的OKT4缺陷是异质性的，排除了抗OKT4自身抗体对OKT4表位的干扰。原发性干燥综合征和银屑病罕见地共存，这暗示了由于CD4异常表型导致的免疫紊乱。
