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2
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本文引用的文献

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Studies on the virus of rabbit papilloma. 1. Methods of assay.兔乳头瘤病毒研究。1. 测定方法。
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Prospects for cervical cancer vaccines.宫颈癌疫苗的前景。
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Synthesis and assembly of infectious bovine papillomavirus particles in vitro.传染性牛乳头瘤病毒颗粒的体外合成与组装
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Efficient self-assembly of human papillomavirus type 16 L1 and L1-L2 into virus-like particles.人乳头瘤病毒16型L1和L1-L2高效自组装成病毒样颗粒。
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Erythrocyte P antigen: cellular receptor for B19 parvovirus.红细胞P抗原：细小病毒B19的细胞受体。
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Three-dimensional structure of vaccinia virus-produced human papillomavirus type 1 capsids.痘苗病毒产生的1型人乳头瘤病毒衣壳的三维结构。
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A virus-like particle enzyme-linked immunosorbent assay detects serum antibodies in a majority of women infected with human papillomavirus type 16.一种病毒样颗粒酶联免疫吸附测定法可检测出大多数感染人乳头瘤病毒16型的女性血清中的抗体。
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Identification and characterization of the cell surface 70-kilodalton sialoglycoprotein(s) as a candidate receptor for encephalomyocarditis virus on human nucleated cells.鉴定并表征细胞表面70千道尔顿唾液酸糖蛋白作为人有核细胞上脑心肌炎病毒的候选受体。
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Interaction of papillomaviruses with the cell surface.乳头瘤病毒与细胞表面的相互作用。
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乳头瘤病毒L1衣壳通过一种蛋白质受体凝集小鼠红细胞。

Papillomavirus L1 capsids agglutinate mouse erythrocytes through a proteinaceous receptor.

作者信息

Roden R B, Hubbert N L, Kirnbauer R, Breitburd F, Lowy D R, Schiller J T

机构信息

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, Maryland 20892, USA.

出版信息

J Virol. 1995 Aug;69(8):5147-51. doi: 10.1128/JVI.69.8.5147-5151.1995.

DOI:10.1128/JVI.69.8.5147-5151.1995
PMID:7541848
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC189336/
Abstract

Virus-like particles (VLPs) composed of L1 derived from bovine papillomavirus type 1 (BPV-1), several human papillomavirus types, or cottontail rabbit papillomavirus (CRPV) agglutinated mouse but not human or rat erythrocytes. Treatment of mouse erythrocytes with trypsin prevented hemagglutination (HA) by BPV-1. Sera from rabbits immunized with native CRPV VLPs, which protect against experimental CRPV infection, exhibited high titers of antibodies that inhibited CRPV VLP HA activity, while sera from rabbits immunized with denatured CRPV VLPs or native BPV VLPs, which do not protect against CRPV infection, were not inhibitory. Testing for HA inhibition is a rapid and simple method for examining the serological relatedness of papillomaviruses and measuring protective antibody titers after VLP vaccination.

摘要

由源自1型牛乳头瘤病毒（BPV-1）、多种人乳头瘤病毒类型或棉尾兔乳头瘤病毒（CRPV）的L1组成的病毒样颗粒（VLP）能凝集小鼠红细胞，但不能凝集人或大鼠红细胞。用胰蛋白酶处理小鼠红细胞可防止BPV-1引起的血凝反应（HA）。用天然CRPV VLP免疫的兔子血清可预防实验性CRPV感染，其抗体滴度较高，能抑制CRPV VLP的HA活性，而用变性CRPV VLP或天然BPV VLP免疫的兔子血清（不能预防CRPV感染）则无抑制作用。HA抑制试验是一种快速简便的方法，可用于检测乳头瘤病毒的血清学相关性以及测量VLP疫苗接种后的保护性抗体滴度。