吲哚菁绿血管造影术在隐匿性脉络膜新生血管中的选择性应用。

Selective use of indocyanine green angiography for occult choroidal neovascularization.

作者信息

Lim J I, Sternberg P, Capone A, Aaberg T M, Gilman J P

机构信息

Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.

出版信息

Am J Ophthalmol. 1995 Jul;120(1):75-82. doi: 10.1016/s0002-9394(14)73761-4.

DOI:10.1016/s0002-9394(14)73761-4

PMID:7541939

Abstract

PURPOSE

Indocyanine green angiography is useful in situations where fluorescein angiography shows occult choroidal neovascularization or pigment epithelial detachment. We sought to determine how often the selective application of indocyanine green angiography results in useful information for eyes with occult choroidal neovascularization.

METHODS

We reviewed 153 consecutive indocyanine green angiograms and identified 77 in which corresponding fluorescein angiograms showed occult choroidal neovascularization or pigment epithelial detachment. We examined the indocyanine green angiograms to detect areas of hyperfluorescence and to classify the margins of hyperfluorescence as well demarcated or poorly demarcated.

RESULTS

Of 77 eyes, 42 (55%) eyes had occult choroidal neovascularization by fluorescein angiography, seven (9%) eyes had both classic and occult choroidal neovascularization by fluorescein angiography, and 28 (36%) eyes had pigment epithelial detachments. Of 42 eyes with occult choroidal neovascularization by fluorescein angiography, 21 (50%) had well-demarcated margins, 13 (31%) had poorly demarcated margins, and eight (19%) had no detectable hyperfluorescence by indocyanine green angiography. Of seven eyes with both classic and occult choroidal neovascularization by fluorescein angiography, two had both poorly demarcated and well-demarcated borders, two had only poorly demarcated borders, and three had well-demarcated borders by indocyanine green. The indocyanine green angiogram showed 23 (82%) of 28 pigment epithelial detachments to have well-demarcated borders of hyperfluorescence; 13 (57%) of 23 were treated.

CONCLUSION

Indocyanine green angiography adds clinically useful information to fluorescein angiography by demonstrating well-demarcated areas of hyperfluorescence in 50% of eyes selected because of diagnosis of occult choroidal neovascularization and in 82% of eyes selected because of pigment epithelial detachment.

摘要

目的

吲哚菁绿血管造影在荧光素血管造影显示隐匿性脉络膜新生血管或色素上皮脱离的情况下很有用。我们试图确定选择性应用吲哚菁绿血管造影对于隐匿性脉络膜新生血管的眼睛能提供有用信息的频率。

方法

我们回顾了153例连续的吲哚菁绿血管造影图像，并确定其中77例相应的荧光素血管造影显示隐匿性脉络膜新生血管或色素上皮脱离。我们检查吲哚菁绿血管造影图像以检测高荧光区域，并将高荧光边缘分类为边界清晰或边界不清。

结果

在77只眼中，42只（55%）眼通过荧光素血管造影显示隐匿性脉络膜新生血管，7只（9%）眼通过荧光素血管造影显示典型和隐匿性脉络膜新生血管，28只（36%）眼有色素上皮脱离。在42只通过荧光素血管造影显示隐匿性脉络膜新生血管的眼中，21只（50%）边缘清晰，13只（31%）边缘不清，8只（19%）通过吲哚菁绿血管造影未检测到高荧光。在7只通过荧光素血管造影显示典型和隐匿性脉络膜新生血管的眼中，2只边界不清和清晰，2只仅边界不清，3只通过吲哚菁绿血管造影边界清晰。吲哚菁绿血管造影显示28只色素上皮脱离眼中的23只（82%）有边界清晰的高荧光边界；23只中的13只（57%）接受了治疗。