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抑制单胺氧化酶B可预防摇头丸引起的纹状体神经毒性。

Inhibition of MAO-B protects against MDMA-induced neurotoxicity in the striatum.

作者信息

Sprague J E, Nichols D E

机构信息

Department of Pharmacology and Toxicology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907, USA.

出版信息

Psychopharmacology (Berl). 1995 Apr;118(3):357-9. doi: 10.1007/BF02245967.

DOI:10.1007/BF02245967
PMID:7542394
Abstract

The effects of the MAO-B inhibitors, L-deprenyl and MDL-72974 on MDMA-induced serotonergic neurotoxicity in rats were examined. MDMA alone produced a significant decrease in the number of 5-HT uptake sites, measured as a decrease in the Bmax for binding of [3H]paroxetine, and in 5-HT and 5-HIAA levels in the striatum. L-Deprenyl and MDL-72974 attenuated this MDMA-induced decrease in serotonergic markers. The data suggest a key role for MAO-B in the expression of the neurotoxicity produced by MDMA in the striatum.

摘要

研究了单胺氧化酶B（MAO-B）抑制剂L-司来吉兰和MDL-72974对摇头丸（MDMA）诱导的大鼠5-羟色胺能神经毒性的影响。单独使用MDMA可使5-羟色胺（5-HT）摄取位点数量显著减少，表现为[3H]帕罗西汀结合的最大结合量（Bmax）降低，同时纹状体中5-HT和5-羟吲哚乙酸（5-HIAA）水平也降低。L-司来吉兰和MDL-72974减轻了MDMA诱导的这些5-羟色胺能标志物的减少。数据表明MAO-B在MDMA诱导的纹状体神经毒性表达中起关键作用。

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