Enhancement of the activity of bleomycin by cysteamine in a micronucleus assay in G0 human lymphocytes.
作者信息
Hoffmann G R, Littlefield L G
机构信息
Department of Biology, College of the Holy Cross, Worcester, MA 01610, USA.
出版信息
Toxicol Lett. 1995 Jul;78(2):147-51. doi: 10.1016/0378-4274(95)03248-j.
PMID:7542408
Abstract
The aminothiol cysteamine enhances the induction of micronuclei by bleomycin in G0 human lymphocytes. The potentiation of bleomycin (12.5, 25, 50, or 100 micrograms/ml) increased with cysteamine concentration from 5 to 20 mM in a 2-h treatment before culturing the cells for the cytokinesis-block assay. The maximum clastogenic activity of bleomycin in the presence of cysteamine was more than 10-fold greater than that of the same dosage of bleomycin alone. Both the thiol and amine functions of aminothiols seem to contribute to the potentiation of bleomycin.
摘要
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引用本文的文献
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