Maes M, Wauters A, Neels H, Scharpé S, Van Gastel A, D'Hondt P, Peeters D, Cosyns P, Desnyder R
Department of Psychiatry, University Hospital of Cleveland, OH, USA.
J Affect Disord. 1995 Apr 16;34(1):61-9. doi: 10.1016/0165-0327(94)00106-j.
Recently, it has been reported that major depression is accompanied by changes in plasma protein concentrations indicative of an acute-phase protein (APP) response. The purpose of the present study was to examine total serum protein (TSP) and the electrophoretically separated major fractions of serum proteins (SP), i.e., albumin (Alb), alpha 1, alpha 2, beta and gamma globulin, in depression. Highly significant differences were found in TSP and the separated SP fractions between major depressed patients and normal controls and between melancholic and minor depressed patients. Major depressed subjects showed significantly lower TSP and Alb concentrations and a higher percentage of the alpha 1 globulin fraction than normal controls and minor depressed subjects. Major depressed subjects had significantly higher and lower percentages, respectively, of alpha 2 and gamma globulin fractions than normal controls. In depressed subjects, there were significant negative correlations between TSP or Alb concentrations and severity of illness. Psychomotor retardation and anorexia were psychopathological correlates of lower TSP and Alb concentrations while middle insomnia and psychomotor retardation were related to changes in the alpha 2 globulin fractions. Basal plasma cortisol values were significantly and positively related to serum alpha 2 globulin. The results support the view that major depression is accompanied by an APP response.
最近，有报道称重度抑郁症伴有血浆蛋白浓度变化，提示急性期蛋白（APP）反应。本研究的目的是检测抑郁症患者的总血清蛋白（TSP）以及血清蛋白（SP）经电泳分离后的主要组分，即白蛋白（Alb）、α1、α2、β和γ球蛋白。在重度抑郁症患者与正常对照组之间以及抑郁性抑郁症患者与轻度抑郁症患者之间，TSP和分离出的SP组分存在高度显著差异。重度抑郁症患者的TSP和Alb浓度显著低于正常对照组和轻度抑郁症患者，且α1球蛋白组分的百分比高于正常对照组和轻度抑郁症患者。重度抑郁症患者的α2和γ球蛋白组分的百分比分别显著高于和低于正常对照组。在抑郁症患者中，TSP或Alb浓度与疾病严重程度之间存在显著负相关。精神运动迟缓及厌食与较低的TSP和Alb浓度存在精神病理学关联，而中度失眠和精神运动迟缓与α2球蛋白组分的变化有关。基础血浆皮质醇值与血清α2球蛋白显著正相关。这些结果支持了重度抑郁症伴有APP反应这一观点。
