Bjerrum K B
Department of Ophthalmology, Rigshospitalet, Copenhagen, Denmark.
Acta Ophthalmol Scand. 1995 Feb;73(1):33-6. doi: 10.1111/j.1600-0420.1995.tb00009.x.
The aim of this study was to investigate the prevalence of snake-like chromatin in the nuclei of conjunctival cells of normal elderly persons, and to compare with findings in patients with connective tissue diseases other than primary Sjögren's syndrome and in age-matched patients with primary Sjögren's syndrome. Thirty-nine per cent of the eyes of normal controls contained snake-like chromatin. Snake-like chromatin has almost never been found in young normals, and the results of this study therefore raise the question of whether age may be a contributing factor. Snake-like chromatin was as frequent in patients with other connective tissue diseases as in patients with primary Sjögren's syndrome, and no correlation to the presence of keratoconjunctivitis sicca was found in this group. The presence of snake-like chromatin was significantly correlated to increased cell size (N/C ratio) and low goblet cell density. A marked correlation between snake-like chromatin and low values of break-up time was found in normals, whereas no correlation was found to the other standard tests for dry eye.
本研究的目的是调查正常老年人结膜细胞核中蛇样染色质的患病率，并与除原发性干燥综合征以外的结缔组织病患者以及年龄匹配的原发性干燥综合征患者的结果进行比较。正常对照组39%的眼睛含有蛇样染色质。在年轻正常人中几乎从未发现过蛇样染色质，因此本研究结果提出了年龄是否可能是一个促成因素的问题。蛇样染色质在其他结缔组织病患者中的出现频率与原发性干燥综合征患者相同，且在该组中未发现与干燥性角结膜炎的存在相关。蛇样染色质的存在与细胞大小增加（核/质比）和杯状细胞密度低显著相关。在正常人中发现蛇样染色质与泪膜破裂时间低值之间存在显著相关性，而与其他干眼标准检查未发现相关性。
