Terai A, Kawakita M, Yoshida O
Department of Urology, Faculty of Medicine, Kyoto University, Japan.
Int J Urol. 1994 Jun;1(2):167-71. doi: 10.1111/j.1442-2042.1994.tb00028.x.
Between 1971 and 1993, 12 children with testicular germ cell tumors were treated at the Department of Urology, Faculty of Medicine, Kyoto University. Seven patients had yolk sac tumors and 5 had mature teratoma. Of the 7 patients with yolk sac tumors 6 had stage I and 1 had stage III tumors. Initial management of the stage I tumors consisted of high orchiectomy in 5 patients and high orchiectomy plus retroperitoneal lymph node dissection in 1 patient. Of these 6 patients, 4 were cured by surgery alone but lung metastases developed in the other 2 patients. One of them was salvaged with thoracotomy and chemotherapy but the other died of tumor. The patient with stage III tumor had bulky tumor spread to lung and retroperitoneum, but seems to have been cured by chemotherapy followed by resection of the residual mass although follow-up is still inadequate (14 months). Six of the 7 patients (85.7%) are alive 13 months to 21 years after diagnosis. Five patients with mature teratoma were treated by high orchiectomy or, more recently, enucleation and all are alive 4 months to 22 years after surgery.
1971年至1993年间，京都大学医学部泌尿外科收治了12例睾丸生殖细胞肿瘤患儿。其中7例为卵黄囊瘤，5例为成熟畸胎瘤。7例卵黄囊瘤患者中，6例为Ⅰ期肿瘤，1例为Ⅲ期肿瘤。Ⅰ期肿瘤的初始治疗包括5例行高位睾丸切除术，1例行高位睾丸切除术加腹膜后淋巴结清扫术。这6例患者中，4例仅通过手术治愈，但另外2例出现了肺转移。其中1例经开胸手术和化疗挽救，但另1例死于肿瘤。Ⅲ期肿瘤患者的肿瘤广泛扩散至肺和腹膜后，但尽管随访时间仍不足（14个月），但似乎通过化疗后切除残留肿块已治愈。7例患者中有6例（85.7%）在诊断后13个月至21年仍存活。5例成熟畸胎瘤患者接受了高位睾丸切除术，或最近采用的肿瘤剜除术，术后4个月至22年全部存活。
