一氧化氮（NO）合成抑制对甲基苯丙胺刻板行为和运动刺激作用超敏反应发展的影响。

Effects of nitric oxide (NO) synthesis inhibition on the development of supersensitivity to stereotypy and locomotion stimulating effects of methamphetamine.

作者信息

Abekawa T, Ohmori T, Koyama T

机构信息

Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan.

出版信息

Brain Res. 1995 May 15;679(2):200-4. doi: 10.1016/0006-8993(95)00207-7.

DOI:10.1016/0006-8993(95)00207-7

PMID:7543354

Abstract

The present study examined the effects of nitric oxide (NO) synthase inhibitor, N omega-nitro-L-arginine methyl ester (LNAME; 30 and 60 mg/kg, i.p.) on the development of supersensitivity to stereotypy as well as locomotion stimulating effects of methamphetamine (MA) (3.22 and 0.805 mg free base/kg, s.c., respectively). Rats treated with MA for 10 days showed enhancement in MA-induced stereotypy and locomotor activity. Rats pretreated with LNAME prior to MA also showed enhancement in the two types of behavior, also they showed significantly reduced stereotypy scores compared to those treated with MA alone. The results suggest that NO synthesis is not critically involved in the development of behavioral supersensitivity to stereotypy stimulating as well as locomotion stimulating effect of MA. However, No synthesis may have a modulatory role in behavioral sensitization in stereotypy.

摘要

本研究考察了一氧化氮（NO）合酶抑制剂Nω-硝基-L-精氨酸甲酯（LNAME；腹腔注射，剂量分别为30和60mg/kg）对甲基苯丙胺（MA）（游离碱剂量分别为3.22和0.805mg/kg，皮下注射）诱导的刻板行为超敏反应以及运动刺激效应发展的影响。用MA处理10天的大鼠表现出MA诱导的刻板行为和运动活性增强。在MA给药前用LNAME预处理的大鼠也表现出这两种行为增强，而且与单独用MA处理的大鼠相比，它们的刻板行为评分显著降低。结果表明，NO合成在对MA的刻板行为刺激及运动刺激效应的行为超敏反应发展中并非关键因素。然而，NO合成可能在刻板行为的行为敏化中具有调节作用。