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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

MRC Group in Lung Development, Hospital for Sick Children Research Institute, University of Toronto Faculty of Medicine, Ontario, Canada.

Gen Pharmacol. 1995 Jul;26(4):755-63. doi: 10.1016/0306-3623(94)00247-k.

The apical membrane of fetal distal lung epithelium had two types of amiloride-blockable Na(+)-permeant cation channels; (1) nonselective cation (NSC) channel with a single channel conductance of 27 pS and (2) Na+ channel with a single channel conductance of 12 pS around resting membrane potential. 2. The IC50 of amiloride to the Na+ channel was 1-2 microM, while the IC50 of amiloride to the NSC channel was less 1 microM. The open probability of the Na+ channel was about 10-fold larger than that of the NSC channel. 3. Insulin (100 nM) increased the open probability of both channels.

MRC Group in Lung Development, Hospital for Sick Children Research Institute, University of Toronto Faculty of Medicine, Ontario, Canada.

Gen Pharmacol. 1995 Jul;26(4):755-63. doi: 10.1016/0306-3623(94)00247-k.

The apical membrane of fetal distal lung epithelium had two types of amiloride-blockable Na(+)-permeant cation channels; (1) nonselective cation (NSC) channel with a single channel conductance of 27 pS and (2) Na+ channel with a single channel conductance of 12 pS around resting membrane potential. 2. The IC50 of amiloride to the Na+ channel was 1-2 microM, while the IC50 of amiloride to the NSC channel was less 1 microM. The open probability of the Na+ channel was about 10-fold larger than that of the NSC channel. 3. Insulin (100 nM) increased the open probability of both channels.