O'Rourke J, Mendeloff T, D'Amato D P
Trans Am Ophthalmol Soc. 1978;76:156-71.
Multiple-point recordings of the initial slopes of xenon 133 and human serum albumin I125 washout from various ocular regions were utilized to visualize changes in capillary and aqueous humor bulk flow in vivo. Preservation of slope linearity is essential for sensitive responsiveness of recordings to flow change. Linearity is enhanced by the initial slope approach in which stability of physiological values and drug effects are maintained and slopes are closely fitted to multiple points. As examples of intraocular flow changes which may be observed and computed from such slopes, responses recorded in forty feline washout studies are presented and the fundamentals of washout recording interpretation are discussed.
利用对来自不同眼部区域的氙133和人血清白蛋白I125清除率初始斜率进行的多点记录，来观察体内毛细血管和房水总体流动的变化。斜率线性的保持对于记录对流量变化的敏感反应至关重要。通过初始斜率法可增强线性，该方法能维持生理值和药物效应的稳定性，并使斜率与多个点紧密拟合。作为可从此类斜率观察和计算的眼内流量变化示例，展示了在40项猫清除率研究中记录的反应，并讨论了清除率记录解读的基本原理。
