一名急性髓系白血病患者的“干细胞样”白血病细胞中存在4号染色体三体。
Trisomy 4 in 'stem cell-like' leukemic cells of a patient with AML.
作者信息
Feuring-Buske M, Haase D, Könemann S, Troff C, Grove D, Hiddemann W, Wörmann B
机构信息
Department of Internal Medicine, Georg-August-Universität, Göttingen, Germany.
出版信息
Leukemia. 1995 Aug;9(8):1318-20.
CD34 positive progenitor cells were analyzed in the bone marrow aspirate from a patient with newly diagnosed AML FAB M4. The patient had trisomy 4 as sole cytogenetic abnormality and a dominant population of CD34 negative leukemic blasts. Karyotyping of the FACS isolated, minor subpopulation of CD34+/CD38-, 'stem cell'-like cells (incidence 0.29%) revealed trisomy 4 in 11/13 metaphases. No metaphases were obtained in the CD34 negative subpopulation. The experiments point to the existence of leukemic stem cells in the CD34+/CD38- compartment in AML patients with trisomy 4.
对一名新诊断为急性髓系白血病FAB M4型患者的骨髓穿刺液中的CD34阳性祖细胞进行了分析。该患者唯一的细胞遗传学异常为4号染色体三体，且存在占主导地位的CD34阴性白血病原始细胞。对通过荧光激活细胞分选术分离出的少量CD34+/CD38-“干细胞”样细胞亚群（发生率为0.29%）进行核型分析，结果显示13个中期分裂相中11个存在4号染色体三体。在CD34阴性亚群中未获得中期分裂相。这些实验表明，在4号染色体三体的急性髓系白血病患者中，CD34+/CD38-细胞区室中存在白血病干细胞。
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