1型人类免疫缺陷病毒整合酶突变体分析
Analysis of human immunodeficiency virus type 1 integrase mutants.
作者信息
Ansari-Lari M A, Donehower L A, Gibbs R A
机构信息
Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA.
出版信息
Virology. 1995 Aug 1;211(1):332-5. doi: 10.1006/viro.1995.1412.
The human immunodeficiency virus type-1 (HIV-1) integrase protein (IN) mediates the insertion of linear double-stranded viral DNA into the host genome. Mutations in IN can have different effects on the virus life cycle. In this study, Gag-Pol polyprotein processing, Tat synthesis, and viral replication were investigated in integrase-defective HIV-1 mutants. In the absence of IN synthesis, the Gag-Pol polyprotein stability, packaging, and/or processing was reduced. There was limited expression of Tat observed in IN mutants, but no viral replication.
1型人类免疫缺陷病毒（HIV-1）整合酶蛋白（IN）介导线性双链病毒DNA插入宿主基因组。IN中的突变可对病毒生命周期产生不同影响。在本研究中，对整合酶缺陷型HIV-1突变体的Gag-Pol多蛋白加工、Tat合成及病毒复制进行了研究。在缺乏IN合成的情况下，Gag-Pol多蛋白的稳定性、包装和/或加工能力降低。在IN突变体中观察到Tat表达有限，但无病毒复制。
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