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[单剂量注射粒细胞集落刺激因子（非格司亭）治疗转移性乳腺癌化疗所致骨髓抑制后的持续性粒细胞增多症和高尿酸血症]

[Persistent granulocytosis and hyperuricemia after a single G-CSF injection (Filgrastim) in treatment of chemotherapy-induced myelosuppression in metastatic breast carcinoma].

作者信息

Hofmann M, Mahlke M, Casper F, Brockerhoff P

机构信息

Universitätsfrauenklinik Mainz.

出版信息

Zentralbl Gynakol. 1995;117(6):314-6.

PMID:7544054
Abstract

We report about a patient with metastatic breast cancer treated with chemotherapy regime (CMF), who developed a febril leukopenia as well as a hyperuricemia. A single subcutaneous application of 300 micrograms Filgrastim led to a severe overstimulation with leukocytosis of max. 50,000 for about 8 days and hyperuricemia.

摘要

我们报告了一名接受化疗方案（CMF）治疗的转移性乳腺癌患者，该患者出现了发热性白细胞减少症以及高尿酸血症。单次皮下注射300微克非格司亭导致严重的过度刺激，出现了最高达50,000的白细胞增多症，持续约8天，并伴有高尿酸血症。

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