Siergiejko Z, Michalska I, Zietkowski Z, Chyrek-Borowska S
Kliniki Alergologii Akademii Medycznej w Białymstoku.
Pneumonol Alergol Pol. 1995;63(3-4):170-5.
The aim of this study was to determine the relation between specific Bronchial Provocation Test (sBPT), the serum specific IgE level (sIgE) and specific basophil histamine release (Dpt HR) in asthma patients, sensitive to Dermatophagoides pteronyssinus (Dpt). The studies were carried out on 30 mild asthma patients with positive case history and strongly positive skin tests with Dpt. In all the patients were performed following tests: BPT with histamine, serum specific IgE level against Dpt (sIgE Dpt), spontaneous basophil HR (spHR), anti-IgE depended basophil HR (aIgE HR), Dpt depended basophil HR (Dpt HR), sBPT with Dpt (sBPT Dpt). The positive results of sBPT Dpt were observed in 27 patients. Twenty six of them had the early¿ asthmatic response (EAR) at least, 19--dual asthmatic response (EAR and LAR) and isolated late asthmatic response (LAR) demonstrated only one patient. The correlation coefficient (r) between sIgE and Dpt HR was 0.4 p < 0.04, between sIgE and sBPT Dpt r = -0.4, p < 0.03, and between sBPT Dpt and Dpt HR r = -0.37, p < 0.05. The results showed a significant correlation between sIgE and Dpt HR, sIgE and sBPT Dpt, sBPT Dpt and Dpt HR and these tests appear to be of value in casual diagnosis of allergic bronchial asthma, but only sBPT makes possible to observe LAR.
本研究旨在确定对粉尘螨（Dpt）敏感的哮喘患者中特异性支气管激发试验（sBPT）、血清特异性IgE水平（sIgE）和特异性嗜碱性粒细胞组胺释放（Dpt HR）之间的关系。研究对象为30例有阳性病史且对Dpt皮肤试验呈强阳性的轻度哮喘患者。对所有患者进行了以下检查：组胺支气管激发试验、针对Dpt的血清特异性IgE水平（sIgE Dpt）、自发性嗜碱性粒细胞组胺释放（spHR）、抗IgE依赖性嗜碱性粒细胞组胺释放（aIgE HR）、Dpt依赖性嗜碱性粒细胞组胺释放（Dpt HR）、Dpt特异性支气管激发试验（sBPT Dpt）。27例患者的sBPT Dpt结果为阳性。其中26例至少有早期哮喘反应（EAR），19例有双重哮喘反应（EAR和LAR），仅1例表现为孤立的晚期哮喘反应（LAR）。sIgE与Dpt HR之间的相关系数（r）为0.4，p<0.04；sIgE与sBPT Dpt之间r=-0.4，p<0.03；sBPT Dpt与Dpt HR之间r=-0.37，p<0.05。结果显示sIgE与Dpt HR、sIgE与sBPT Dpt、sBPT Dpt与Dpt HR之间存在显著相关性，这些检查在过敏性支气管哮喘的临床诊断中似乎具有价值，但只有sBPT能够观察到LAR。
