释放的淋巴细胞蛋白对人淋巴细胞的体外作用。
Effect of released lymphocyte proteins on human lymphocytes in vitro.
作者信息
Szabó M T, Hrabák A A
出版信息
Acta Biochim Biophys Acad Sci Hung. 1978;13(1-2):13-21.
The effect on lymphocytes and Hep2 target cells of proteins obtained from the medium of human lymphocytes incubated for short times was studied. The supernatants were precipitated and fractionated with ammonium sulfate in three steps. Two protein fractions were found to inhibit protein synthesis in target cells and to increase in vitro release of chromium from prelabelled lymphocytes. The proteins studied may be related to lymphotoxin produced by mitogen-activated lymphocytes. It is assumed that in vitro interactions for short times between different types of lymphocytes may cause the release of proteins. The same proteins play probably a part in the in vivo regulation of the metabolic activity of lymphocytes.
研究了短时间培养的人淋巴细胞培养基中获得的蛋白质对淋巴细胞和Hep2靶细胞的影响。将上清液沉淀并用硫酸铵分三步分级分离。发现两个蛋白质级分可抑制靶细胞中的蛋白质合成，并增加预标记淋巴细胞中铬的体外释放。所研究的蛋白质可能与有丝分裂原激活的淋巴细胞产生的淋巴毒素有关。假定不同类型淋巴细胞之间短时间的体外相互作用可能导致蛋白质释放。相同的蛋白质可能在体内淋巴细胞代谢活性的调节中起作用。
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