Kanyár B
Acta Biochim Biophys Acad Sci Hung. 1978;13(3):153-60.
For the Michaelis-Menten binding kinetics and for a two- and a three-compartmental model a parameter sensitivity analysis is performed to design experiments. According to the mathematical results in the case of the binding kinetics the substrate concentrations s approximately Km are optimal in view to the variance of the Michaelis constant Km. In the case of the two-compartment model the results of the calculations are tested by the use of computer-simulated data. The correspondence between the sensitivity and simulation results is satisfactory.
对于米氏结合动力学以及两室和三室模型，进行参数敏感性分析以设计实验。根据结合动力学情况下的数学结果，就米氏常数Km的方差而言，底物浓度s约为Km时是最优的。在两室模型的情况下，通过使用计算机模拟数据对计算结果进行检验。敏感性分析结果与模拟结果之间的一致性令人满意。
