Achakri H, Stergiopulos N, Hoogerwerf N, Hayoz D, Brunner H R, Meister J J
Biomedical Engineering Laboratory, Swiss Federal Institute of Technology, Lausanne.
J Vasc Res. 1995 Jul-Aug;32(4):237-46. doi: 10.1159/000159098.
Arterial vasomotion and its relation to intraluminal pressure were investigated in vitro in isolated rat arteries. Femoral arteries (mean diameter = 768.2 +/- 25 microns, n = 5) and mesenteric arteries (mean diameter = 393.4 +/- 32 microns, n = 5) were used in this study. Arterial segments were excised, mounted on microcannulas and perfused with Tyrode's solution at a constant flow (100 microliters/min). After equilibration, intraluminal pressure was stepwise changed from 0 to 120 mm Hg. The changes in the outer diameter of the vessels were measured continuously over a period of 4 h after the equilibration. Vasomotion was induced by constrictor agonists (norepinephrine 10(-6) M for mesenteric arteries and norepinephrine 10(-6) M + Bay K8644 10(-7) M for femoral arteries) and was maintained only in the presence of the above-mentioned drugs. Both vasomotion magnitude and frequency are modulated by pressure. Vasomotion frequency increases with pressure increase. When intraluminal pressure varied between 0 and 120 mm Hg, vasomotion frequency varied between 0.19 and 0.49 Hz for mesenteric arteries and between 0.04 and 0.23 Hz for femoral arteries. Thus, vasomotion frequency differed clearly between the two vessel types. Vasomotion amplitude shows a biphasic relationship with a maximum occurring at about 40 mm Hg for mesenteric arteries and 50 mm Hg for femoral arteries. Based on these findings, it is hypothesized that vasomotion amplitude relates to the active mechanical properties of the artery and, in particular, to its contractile capacity.
在体外对分离的大鼠动脉进行了动脉血管运动及其与管腔内压力关系的研究。本研究使用了股动脉（平均直径 = 768.2 ± 25微米，n = 5）和肠系膜动脉（平均直径 = 393.4 ± 32微米，n = 5）。切取动脉段，安装在微插管上，并用台氏液以恒定流量（100微升/分钟）灌注。平衡后，管腔内压力从0逐步变化至120毫米汞柱。在平衡后的4小时内持续测量血管外径的变化。血管运动由收缩激动剂诱导（肠系膜动脉用去甲肾上腺素10⁻⁶摩尔/升，股动脉用去甲肾上腺素10⁻⁶摩尔/升 + 巴氯芬8644 10⁻⁷摩尔/升），且仅在上述药物存在时维持。血管运动的幅度和频率均受压力调节。血管运动频率随压力升高而增加。当管腔内压力在0至120毫米汞柱之间变化时，肠系膜动脉的血管运动频率在0.19至0.49赫兹之间变化，股动脉的血管运动频率在0.04至0.23赫兹之间变化。因此，两种血管类型的血管运动频率明显不同。血管运动幅度呈现双相关系，肠系膜动脉在约40毫米汞柱时出现最大值，股动脉在约50毫米汞柱时出现最大值。基于这些发现，推测血管运动幅度与动脉的主动力学特性有关，特别是与其收缩能力有关。
