Ling J J, Yu J, Robertson R T
Department of Anatomy and Neurobiology, College of Medicine, University of California, Irvine 92717, USA.
Brain Res Dev Brain Res. 1995 May 26;86(1-2):354-8. doi: 10.1016/0165-3806(95)00035-c.
Esterase activity of endogenous transiently expressed acetylcholinesterase was locally suppressed in visual cortex of infant rats for 2-5 days by the irreversible inhibitor phospholine iodide, delivered from Elvax implants. Tissue processed for anterograde movement of the carbocyanine dye DiI or anterograde transneuronal transport of wheat germ agglutinin-horseradish peroxidase revealed normal geniculocortical growth into layer IV of visual cortex. These results suggest that the catalytic activity of transiently expressed acetylcholinesterase may play little, if any, role in early development of thalamocortical systems.
通过从乙烯-醋酸乙烯共聚物（Elvax）植入物释放的不可逆抑制剂碘化磷酰胆碱，在幼鼠视觉皮层中局部抑制内源性瞬时表达的乙酰胆碱酯酶的酯酶活性达2至5天。经处理用于羰花青染料DiI顺行移动或小麦胚芽凝集素-辣根过氧化物酶顺行跨神经元运输的组织显示，膝状体-皮层正常生长至视觉皮层的第IV层。这些结果表明，瞬时表达的乙酰胆碱酯酶的催化活性在丘脑-皮层系统的早期发育中即便有作用，也可能很小。
