Kishegyi J, Horváth G, Kövér G
Acta Physiol Acad Sci Hung. 1978;52(1):63-70.
The Evans-blue distribution volume, haematocrit, and plasma protein concentration were investigated in non-hydrated (control), hydrated, and acutely nephrectomized hydrated, anaesthetized dogs. In control anaesthetized dogs a decrease of the plasma protein level was observed as part of the plasma proteins was lost into the extravascular space and did not return into the circulating plasma during the experimental period. Under the effect of hydration, the Evans-blue distribution volume increased significantly, while the haematocrit and plasma volume did not change. The phenomenon was ascribed to an increase in capillary permeability. During hydration following acute nephrectomy, the Evans-blue distribution volume increased but the haematocrit disecreased and the circulating plasma volume increased. It is concluded that a material (or materials) orginating from the kidney may influence capillary permeability.
在未水化（对照）、水化以及急性肾切除并水化的麻醉犬中，研究了伊文思蓝分布容积、血细胞比容和血浆蛋白浓度。在对照麻醉犬中，观察到血浆蛋白水平下降，因为部分血浆蛋白在实验期间进入血管外间隙且未回到循环血浆中。在水化作用下，伊文思蓝分布容积显著增加，而血细胞比容和血浆容积未改变。该现象归因于毛细血管通透性增加。急性肾切除后的水化过程中，伊文思蓝分布容积增加，但血细胞比容降低且循环血浆容积增加。得出的结论是，源自肾脏的一种（或多种）物质可能影响毛细血管通透性。
