Yang D X, He K Q, Cheng G F
Department of Pharmacology, Chinese Academy of Medical Sciences, Beijing.
Yao Xue Xue Bao. 1995;30(4):254-7.
The effect of tremulacin (TRC) extracted from Mao Bai Yang (Folia Populus tomentosa Carr) on actions of SRS-A and histamine were investigated by using isolated guinea pig ileum and spectrofluorometric assay. TRC was found to inhibit the contraction of isolated guinea pig ileum induced by histamine and SRS-A, in a dose-dependent manner with IC50 of 1.78 x 10(-4) mol.L-1 and 2.51 x 10(-4) mol.L-1, respectively. TRC at the dose of 10(-4) mol.L-1 inhibited SRS-A release from sensitized isolated guinea pig lung. While at the dose of 10(-5) mol.L-1 inhibited histamine release from the peritoneal mast cells in sensitized rats. These results indicate that inhibition of the release of histamine and SRS-A may play an important role in the mechanism of antiinflammatory actions of TRC.
采用离体豚鼠回肠和荧光分光光度法，研究了从毛白杨（毛白杨叶）中提取的震颤素（TRC）对SRS - A和组胺作用的影响。发现TRC能抑制组胺和SRS - A诱导的离体豚鼠回肠收缩，呈剂量依赖性，IC50分别为1.78×10⁻⁴mol·L⁻¹和2.51×10⁻⁴mol·L⁻¹。10⁻⁴mol·L⁻¹剂量的TRC抑制致敏离体豚鼠肺中SRS - A的释放。而10⁻⁵mol·L⁻¹剂量的TRC抑制致敏大鼠腹腔肥大细胞中组胺的释放。这些结果表明，抑制组胺和SRS - A的释放可能在TRC抗炎作用机制中起重要作用。
