内毒素是通过模拟神经酰胺来刺激细胞的吗？
Does endotoxin stimulate cells by mimicking ceramide?
作者信息
Wright S D, Kolesnick R N
机构信息
Laboratory of Cellular Physiology and Immunology, Rockefeller University, New York, NY 10021, USA.
出版信息
Immunol Today. 1995 Jun;16(6):297-302. doi: 10.1016/0167-5699(95)80185-5.
PMID:7544978
Abstract
Recent studies indicate that tumor necrosis factor (TNF) and interleukin 1 (IL-1) stimulate cells via the intracellular messenger ceramide. Bacterial endotoxin (lipopolysaccharide; LPS) shows strong structural and functional resemblance to ceramide. Here, Samuel Wright and Richard Kolesnick review data suggesting that LPS may provoke cellular responses by mimicking the action of ceramide.
摘要
近期研究表明，肿瘤坏死因子（TNF）和白细胞介素1（IL-1）通过细胞内信使神经酰胺刺激细胞。细菌内毒素（脂多糖；LPS）在结构和功能上与神经酰胺有很强的相似性。在此，塞缪尔·赖特和理查德·科尔斯尼克回顾了相关数据，这些数据表明LPS可能通过模拟神经酰胺的作用引发细胞反应。
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