Hahka-Kemppinen M, Muhonen T, Virolainen M, Jekunen A, Asko-Seljavaara S, Pyrhönen S
Department of Radiotherapy and Oncology, Helsinki University Central Hospital, Finland.
Br J Dermatol. 1995 Jun;132(6):973-7. doi: 10.1111/j.1365-2133.1995.tb16958.x.
A chemotherapy regimen consisting of dacarbazine (DTIC), vincristine, bleomycin and lomustine (CCNU) was combined with natural leucocyte interferon (IFN) in the treatment of 37 patients with cutaneous and subcutaneous metastases of malignant melanoma. Twenty-five also had concomitant lymph node, visceral, bone or brain metastases. Fifteen patients (41%) experienced complete response (CR) and 10 (27%) partial response (PR) of the superficial lesions. In addition, three patients were rendered surgically tumour-free after PR or disease stabilization during drug therapy. The median overall duration of response was 10.2 months (range 1-53 months). In disseminated disease, the combined therapy produced favourable results, particularly with regard to superficial lesions. It is also possible that this therapy may retard the growth of aggressive subcutaneous metastases in patients who have previously had multiple surgical procedures in an attempt to stabilize their disease. In a small proportion of patients, the long-term complete remission with the drug therapy alone, or in combination with surgery, suggests that this regimen might have been curative.
一种由达卡巴嗪（DTIC）、长春新碱、博来霉素和洛莫司汀（CCNU）组成的化疗方案与天然白细胞干扰素（IFN）联合，用于治疗37例恶性黑色素瘤皮肤和皮下转移患者。其中25例还伴有淋巴结、内脏、骨骼或脑转移。15例患者（41%）浅表病灶出现完全缓解（CR），10例（27%）出现部分缓解（PR）。此外，3例患者在PR或药物治疗期间病情稳定后手术切除肿瘤。中位总缓解持续时间为10.2个月（范围1 - 53个月）。在播散性疾病中，联合治疗产生了良好的效果，特别是对于浅表病灶。对于那些此前曾进行多次手术以稳定病情的患者，这种治疗方法也可能延缓侵袭性皮下转移灶的生长。在一小部分患者中，单纯药物治疗或联合手术实现长期完全缓解，提示该方案可能具有治愈性。
