Buyan N, Cinaz P, Hasanoğlu E, Gökçora N, Bircan Z
Gazi University, Faculty of Medicine, Turkey.
Endocr J. 1995 Jun;42(3):429-33. doi: 10.1507/endocrj.42.429.
The significance of serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) levels in uremia is still controversial. In this study we measured serum IGF-I by immunoradiometric assay (IRMA) and IGFBP-3 levels by specific radioimmunoassay (RIA) in 28 children (aged 3-16 years) with end-stage (n = 14, on hemodialysis) and pre-terminal renal failure (n = 14) and in 15 age-matched healthy children. Thyroid function of the patients was also investigated and GH-stimulation tests with L-Dopa and insulin were performed. Neither IGF-I nor IGFBP-3 levels significantly correlated with mean height SDS for bone age or for chronological age in either non dialysis patients or pubertal (n = 10) or prepubertal patients (n = 18). These data was consistent with the concept that growth in CRF was not related to abnormalities in serum IGF-I or IGFBP-3 levels.
血清胰岛素样生长因子I（IGF-I）和胰岛素样生长因子结合蛋白3（IGFBP-3）水平在尿毒症中的意义仍存在争议。在本研究中，我们采用免疫放射分析法（IRMA）测定了28例3至16岁患有终末期（n = 14，接受血液透析）和终末期前肾衰竭（n = 14）的儿童以及15例年龄匹配的健康儿童的血清IGF-I，并采用特异性放射免疫分析法（RIA）测定了IGFBP-3水平。还对患者的甲状腺功能进行了研究，并进行了左旋多巴和胰岛素的生长激素刺激试验。在非透析患者、青春期患者（n = 10）或青春期前患者（n = 18）中，IGF-I和IGFBP-3水平均与骨龄或实际年龄的平均身高标准差无显著相关性。这些数据与慢性肾衰竭患者的生长与血清IGF-I或IGFBP-3水平异常无关的概念一致。
