Ben-Josef E, Lucas D R, Vasan S, Porter A T
Department of Radiation Oncology, Wayne State University, Detroit, Michigan, USA.
Nucl Med Commun. 1995 Jun;16(6):457-63. doi: 10.1097/00006231-199506000-00007.
The systemic administration of 89Sr has proven effective in the palliation of painful osseous metastases. Biodistribution studies with the gamma-emitter 85Sr suggest that both its uptake and retention are increased in bone metastases, where increased mineral turnover takes place. To study the pattern and nature of this process further, bones containing metastatic deposits were obtained from three patients who had previously been treated with 148 MBq of 89Sr. The bones were cut into 0.5-1.0 cm sections. The cut surfaces which faced together were marked with India ink, and adjacent sections were submitted for histology and autoradiography. Strontium deposition and retention were observed in regions which exhibited significant osteoblastic activity, mostly in areas adjacent to metastatic deposits, but also in subchondral and endosteal locations, as well as in an area corresponding to a pathological fracture with callus formation. With these exceptions, strontium deposition was not observed in histologically normal bone or within the marrow. Our findings demonstrate directly the selective nature of accumulation and retention of 89Sr and confirm previous clinical impressions.
已证实全身给予89Sr对缓解骨转移疼痛有效。用γ发射体85Sr进行的生物分布研究表明，在发生矿物质转换增加的骨转移灶中，其摄取和滞留均增加。为了进一步研究这一过程的模式和性质，从三名先前接受过148 MBq 89Sr治疗的患者身上获取了含有转移灶的骨骼。将骨骼切成0.5 - 1.0厘米的切片。相互面对的切面用印度墨水标记，相邻切片送去做组织学检查和放射自显影。在表现出明显成骨细胞活性的区域观察到锶沉积和滞留，主要在转移灶附近区域，但也见于软骨下和骨内膜部位，以及对应于有骨痂形成的病理性骨折区域。除这些部位外，在组织学正常的骨组织或骨髓内未观察到锶沉积。我们的研究结果直接证明了89Sr积累和滞留的选择性，并证实了先前的临床印象。
