Benthin N P
Urologisk-karkirurgisk afdeling H., Amtssygehuset i Gentofte.
Ugeskr Laeger. 1995 Sep 4;157(36):4946-7.
Three patients with Buerger's disease, ischaemic ulcers and pain, accepted treatment with ilomedin, a synthetic stable prostaglandin, as a supplement to standard treatment. The patients were treated intravenously, with ilomedin for six hours daily for 28 days. One patient had total healing of his ulcers just after treatment. The ulcers of the other patients showed almost complete healing about two months after treatment. However, the ulcers then returned to their previous size. Ilomedin was then used as preoperative treatment prior to amputation in order to facilitate healing after amputation. Our conclusions are that we now have a promising drug, ilomedin, in the treatment of patients with Buerger's disease, ulcers and pain, but controlled studies are necessary.
三名患有血栓闭塞性脉管炎、缺血性溃疡和疼痛的患者接受了伊洛前列素（一种合成的稳定前列腺素）治疗，作为标准治疗的补充。患者接受静脉注射伊洛前列素，每天6小时，共28天。一名患者在治疗后溃疡完全愈合。其他患者的溃疡在治疗后约两个月显示几乎完全愈合。然而，溃疡随后又恢复到之前的大小。然后，伊洛前列素被用作截肢术前的治疗，以促进截肢后的愈合。我们的结论是，我们现在有一种有前景的药物伊洛前列素，可用于治疗血栓闭塞性脉管炎、溃疡和疼痛的患者，但需要进行对照研究。
