5-羟基-3-乙烯基-2(5H)-呋喃酮——一种从一种杯盖菌属（担子菌纲）发酵产物中提取的新型人滑膜磷脂酶A2抑制剂和血小板聚集抑制剂。

5-hydroxy-3-vinyl-2(5H)-furanone--a new inhibitor of human synovial phospholipase A2 and platelet aggregation from fermentations of a Calyptella species (basidiomycetes).

作者信息

Lorenzen K, Anke T, Konetschny-Rapp S, Scheuer W

机构信息

LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.

出版信息

Z Naturforsch C J Biosci. 1995 May-Jun;50(5-6):403-9.

PMID:7546033

Abstract

5-Hydroxy-3-vinyl-2(5H)-furanone, a potent and selective inhibitor of human synovial phospholipase A2 was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic methods is identical to PA 147, an antibiotic previously isolated from a streptomycete. 5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregation of human and bovine platelets stimulated by different inducers and exhibits weak antimicrobial activities.

摘要

5-羟基-3-乙烯基-2(5H)-呋喃酮是一种从一种帽贝属物种发酵产物中分离得到的强效且选择性的人滑膜磷脂酶A2抑制剂。通过光谱方法鉴定的其结构与PA 147相同，PA 147是一种先前从链霉菌中分离得到的抗生素。5-羟基-3-乙烯基-2(5H)-呋喃酮可抑制由不同诱导剂刺激的人及牛血小板聚集，并表现出较弱的抗菌活性。