Winkler M, Ringe B, Oldhafer K, Kattner A, Färber L, Maibücher A, Wonigeit K, Pichlmayr R
Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany.
Transpl Int. 1995;8(4):324-6. doi: 10.1007/BF00346888.
We analysed the absorption, after oral application, of a new galenic form of cyclosporin A (CyA-NOF) in liver-grafted patients (n = 12) during the 1st week (days 2-4) after transplantation. Pharmacokinetic profiling was performed with an open or clamped T tube in situ or with the T tube absent. The pharmacokinetic parameters of CyA-NOF were influenced by T tube clamping and bile diversion. The highest AUC, Cmax and earliest Tmax values were found in patients without a T tube in situ, indicating that absorption of CyA-NOF in patients during the early course after liver transplantation is not bile-independent. CyA-NOF, at a dose of 7.5 mg/kg, was enterally absorbed with appropriate AUC and Cmax levels. Patients receiving a starting dose of 7.5 mg/kg were successfully maintained on CyA-NOF during the subsequent clinical course.
我们分析了肝移植患者（n = 12）在移植后第1周（第2 - 4天）口服一种新剂型环孢素A（CyA - NOF）后的吸收情况。通过原位开放或夹闭T管或无T管的方式进行药代动力学分析。CyA - NOF的药代动力学参数受T管夹闭和胆汁引流的影响。原位无T管的患者中观察到最高的AUC、Cmax和最早的Tmax值，这表明肝移植术后早期患者中CyA - NOF的吸收并非不依赖胆汁。剂量为7.5 mg/kg的CyA - NOF经肠道吸收，其AUC和Cmax水平适宜。接受7.5 mg/kg起始剂量的患者在后续临床过程中成功维持了CyA - NOF治疗。
