酒精会增强可卡因乙烯酯对小鼠的致死性。
Cocaethylene-induced lethality in mice is potentiated by alcohol.
作者信息
Meehan S M, Schechter M D
机构信息
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA.
出版信息
Alcohol. 1995 Jul-Aug;12(4):383-5. doi: 10.1016/0741-8329(95)00022-j.
Mice of the heterogeneously bred HS line were concurrently administered intraperitoneal injections of either 95, 75, 60, or 48 mg/kg cocaethylene or 48, 38, or 30 mg/kg cocaethylene in conjunction with the non-lethal dose of 6.0 g/kg (20% w/v) alcohol. Results indicate that alcohol administration significantly potentiated cocaethylene-induced lethality. This observation suggests that alcohol is capable of enhancing the lethal effects of cocaethylene. Results are discussed in terms of observations of sudden death in humans who abuse cocaine and alcohol.
对异种繁殖的HS品系小鼠腹腔注射95、75、60或48mg/kg的可卡因乙烯，或注射48、38或30mg/kg的可卡因乙烯并同时给予非致死剂量6.0g/kg（20%w/v）的酒精。结果表明，给予酒精显著增强了可卡因乙烯诱导的致死性。这一观察结果表明酒精能够增强可卡因乙烯的致死作用。根据对滥用可卡因和酒精的人类猝死情况的观察对结果进行了讨论。
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