胸腺内和胸腺外T细胞的克隆清除。
Intrathymic and extrathymic clonal deletion of T cells.
作者信息
Sprent J, Webb S R
机构信息
Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
出版信息
Curr Opin Immunol. 1995 Apr;7(2):196-205. doi: 10.1016/0952-7915(95)80004-2.
PMID:7546379
Abstract
Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous antigens in the periphery. Recent evidence on the microenvironments, cell-cell interactions and signalling requirements for clonal deletion of immature and mature T cells is discussed.
摘要
克隆清除在胸腺中负责诱导自身耐受性，并且也影响在外周对外部抗原作出反应的成熟T细胞。本文讨论了关于未成熟和成熟T细胞克隆缺失的微环境、细胞间相互作用及信号需求的最新证据。
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