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由抗原受体刺激诱导的即早基因。

Immediate-early genes induced by antigen receptor stimulation.

作者信息

Kelly K, Siebenlist U

机构信息

Laboratory of Pathology, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Curr Opin Immunol. 1995 Jun;7(3):327-32. doi: 10.1016/0952-7915(95)80106-5.

DOI:10.1016/0952-7915(95)80106-5
PMID:7546396
Abstract

Immediate early genes induced by triggering of the TCR frequently encode proteins that act in signal transduction cascades. Recent advances concerning several immediate-early proteins have been made, including signal-induced regulation of NF-kappa B by I kappa-B, the role of Nur77 in T-cell selection and apoptosis, and the function of PAC-1 in regulating the Ras/ERK pathway.

摘要

由TCR触发诱导的即刻早期基因通常编码在信号转导级联反应中起作用的蛋白质。关于几种即刻早期蛋白已有一些新进展，包括Iκ-B对NF-κB的信号诱导调节、Nur77在T细胞选择和凋亡中的作用以及PAC-1在调节Ras/ERK途径中的功能。

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