Mokrzycki M H, Rickles F R, Kaplan A A, Kohn O F
Department of Medicine, University of Connecticut Health Center, Farmington, USA.
Blood Purif. 1995;13(5):271-82. doi: 10.1159/000170210.
Thrombotic thrombocytopenic purpura (TTP) is a rare syndrome which presents typically with thrombocytopenia, microangiopathic hemolytic anemia, central nervous system symptoms, fever, and renal abnormalities. The diagnosis of TTP in pregnancy previously carried a poor prognosis and a high fetal mortality when presenting early in gestation. This case report describes the earliest presentation of TTP in pregnancy (6 weeks of gestation) we could identify in the literature treated successfully with a prolonged course of plasma exchange. The differential diagnosis and the pathogenesis of TTP in pregnancy are reviewed. Therapeutic options and data regarding the removal of pregnancy-related hormones by plasma exchange are presented.
血栓性血小板减少性紫癜（TTP）是一种罕见的综合征，典型表现为血小板减少、微血管病性溶血性贫血、中枢神经系统症状、发热和肾脏异常。妊娠期间诊断为TTP，若在妊娠早期出现，既往预后较差，胎儿死亡率高。本病例报告描述了我们在文献中所能查到的妊娠期间最早出现的TTP（妊娠6周），经长时间血浆置换成功治疗。本文还对妊娠期间TTP的鉴别诊断和发病机制进行了综述。介绍了治疗选择以及关于通过血浆置换去除妊娠相关激素的数据。
