Vamvakidès A
Laboratoire de pharmacologie expérimentale, Faculté de Médecine d'Athènes, Goudi, Grèce.
Boll Chim Farm. 1995 May;134(5):258-62.
N-palmitoyl glycine (PG), synthesized by the mixed anhydrides method, displayed nootropic effects (in the "step-down" test) as well as an anti-immobility action in the forced swimming test, in mice. However no anticonvulsant effects were obtained, even at high dose (300 mg/Kg, po), in the maximal electroshock or against the convulsions induced by pentetrazol. In the study reported in this paper PG potentiated the reserpine or the haloperidol catalepsy in rats. The potentiation of the haloperidol catalepsy was antagonized by imipramine which displayed antiglutamatergic and antimuscarinic properties. On the other hand at 150 mg/Kg (ip), a dose which potentiated the haloperidol catalepsy, PG stimulated the dopaminergic function in the striatum. These results could therefore constitute a first clue suggesting a stimulation, by PG, of the cholinergic and GABAergic interneurons, by glycinergic potentiation of the NMDA receptors in the striatum.
通过混合酸酐法合成的N-棕榈酰甘氨酸（PG）在小鼠的“跳台”试验中显示出益智作用，在强迫游泳试验中也具有抗不动作用。然而，即使在高剂量（300 mg/Kg，口服）下，在最大电休克试验或对抗戊四氮诱导的惊厥试验中，PG也未表现出抗惊厥作用。在本文报道的研究中，PG增强了大鼠的利血平或氟哌啶醇诱导的僵住症。氟哌啶醇诱导的僵住症的增强作用被具有抗谷氨酸能和抗毒蕈碱特性的丙咪嗪所拮抗。另一方面，在150 mg/Kg（腹腔注射）的剂量下，该剂量增强了氟哌啶醇诱导的僵住症，PG刺激了纹状体中的多巴胺能功能。因此，这些结果可能构成了第一条线索，表明PG通过增强纹状体中NMDA受体的甘氨酸能作用来刺激胆碱能和GABA能中间神经元。
