Pincus S, Tartaglia J, Paoletti E
Virogenetics Corporation, Troy, New York 12180, USA.
Biologicals. 1995 Jun;23(2):159-64. doi: 10.1006/biol.1995.0026.
The safety issues surrounding the use of vaccinia-based vaccine candidates have been significantly addressed with the development of the NYVAC and ALVAC vectors. These vectors can be engineered to express multiple genes from the same pathogen or multiple genes from multiple pathogens. The use of these vectors to develop needed vaccines for human and veterinary medicine remains the focus of studies that are currently in progress.
随着NYVAC和ALVAC载体的开发，围绕基于痘苗的候选疫苗使用的安全问题已得到显著解决。这些载体可以经过改造，以表达来自同一病原体的多个基因或来自多种病原体的多个基因。利用这些载体开发人类和兽医学所需的疫苗仍然是当前正在进行的研究重点。
