Sun X F, Carstensen J M, Nordenskjöld B
Department of Oncology, University Hospital of Linköping, Sweden.
Anal Cell Pathol. 1995 Apr;8(3):203-11.
Expression of c-erbB-2 and p53 protein was analysed retrospectively by immunohistochemistry in formalin-fixed tissue samples from 293 patients with colorectal adenocarcinoma. There was a significant positive relationship between c-erbB-2 and p53 expression (P < 0.0001). Co-overexpression of c-erbB-2 and p53 tended to be increased in tumours with infiltrative growth (P = 0.08) and higher S-phase fraction (P = 0.085). In combined survival analysis, patients with tumours in both c-erbB-2 positivity and p53 negativity had a more favourable outcome (P = 0.03). Multivariate analysis revealed that p53 overexpression was significantly associated with poor prognosis independent of c-erbB-2 expression, DNA-ploidy, S-phase fraction, growth pattern and Dukes stage (P = 0.002). We conclude that there is an inter-reaction between the two oncoproteins in the tumour development and that the overexpression of p53 proteins may be a powerful prognostic predictor in colorectal adenocarcinoma.
采用免疫组织化学方法，对293例结肠腺癌患者福尔马林固定组织样本中的c-erbB-2和p53蛋白表达进行回顾性分析。c-erbB-2与p53表达之间存在显著正相关（P < 0.0001）。在浸润性生长的肿瘤（P = 0.08）和较高S期分数的肿瘤（P = 0.085）中，c-erbB-2和p53的共过表达倾向于增加。在联合生存分析中，c-erbB-2阳性且p53阴性的肿瘤患者预后更佳（P = 0.03）。多因素分析显示，p53过表达与预后不良显著相关，且独立于c-erbB-2表达、DNA倍体、S期分数、生长模式和Dukes分期（P = 0.002）。我们得出结论，在肿瘤发生发展过程中这两种癌蛋白之间存在相互作用，并且p53蛋白的过表达可能是结肠腺癌中一个有力的预后预测指标。
