Nghiem D D, Hsia S, Carpenter B J, Chao S H, Marcus R J, Palumbi M A, Paul C L, Kijanka B A, Breckenridge M A, Meleason D F
Department of Surgery, Allegheny General Hospital, Pittsburgh, Pennsylvania, USA.
Clin Transpl. 1994:213-8.
We report our experience with 25 living-donor and 427 cadaveric-donor kidneys followed for over 6 years. Patient survival exceeds 90% at 5 years for all recipients. Overall one-year and 5-year graft survival rates were 82.7% and 65.5%, respectively. Approximately one-third of CAD were of extreme age (eg, < or = 10 and > or = 60 years old). One-year and 5-year GS rates of this group were 72.2% and 54.8%, respectively. Kidneys from elderly donors probably should be given to age-matched recipients. Infant en bloc kidneys had good GS. They also adapted well their growth and function to adult recipients and should be used more frequently to alleviate the organ shortage problem. HLA mismatches, transplant PRA level, original kidney disease, and immunosuppressive regimens significantly affected the GS. Race, sex, cytomegaloviral antibody states, unacceptable antigens, length of pretransplant dialysis, and CAD cold ischemic time had no significant effect on GS.
我们报告了对25个活体供肾和427个尸体供肾进行6年以上随访的经验。所有受者的5年患者生存率超过90%。总体而言，1年和5年移植肾生存率分别为82.7%和65.5%。大约三分之一的尸体供肾者年龄极高（如≤10岁和≥60岁）。该组的1年和5年移植肾生存率分别为72.2%和54.8%。老年供者的肾脏可能应给予年龄匹配的受者。婴儿整块肾具有良好的移植肾生存率。它们在生长和功能上也能很好地适应成年受者，应更频繁地使用以缓解器官短缺问题。HLA错配、移植前群体反应性抗体水平、原发病肾病和免疫抑制方案显著影响移植肾生存率。种族、性别、巨细胞病毒抗体状态、不可接受抗原、移植前透析时间和尸体供肾冷缺血时间对移植肾生存率无显著影响。
