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儿童阑尾切除术后腹腔脓肿的药物治疗

Medical treatment of postappendectomy intraperitoneal abscesses in children.

作者信息

Héloury Y, Baron M, Bourgoin S, Wetzel O, Lejus C, Plattner V

机构信息

Chirurgie Infantile, Hôpital Mère-Enfant, Nantes, France.

出版信息

Eur J Pediatr Surg. 1995 Jun;5(3):149-51. doi: 10.1055/s-2008-1066191.

Abstract

Treatment of postappendectomy intraperitoneal abscesses is classically surgical (drainage). We report a retrospective study (1988 to 1991) of our experience in providing exclusively medical treatment for 11 such isolated abscesses in children. The abscess was detected 7 times within the 10 days following appendectomy. Ultrasonography localized the abscess 7 times in the right iliac fossa and 4 times in Douglas' pouch. In 4 cases it was larger than 5 cm in diameter. Parenteral antibiotic therapy associated ticarcillin and clavulanic acid 6 times and piperacillin, tobramycin and metronidazole 5 times. Drug efficacy was evaluated by clinical signs (fever, pain, ileus) and ultrasonography. In one case, an associated ileus led to reoperation at day 4 of treatment. In the other 10 cases, clinical signs disappeared during the first week of treatment. At day 7, parenteral was replaced by oral antibiotic therapy (metronidazole 7 times, amoxicillin-clavulanic acid 3 times) continued until the abscess was no longer visualized on ultrasonography (5 times at 3 weeks, 5 times at 1 month). Medical treatment of isolated postappendectomy abscesses in children would thus appear to be a logical choice in the absence of an associated ileus.

摘要

阑尾切除术后腹腔内脓肿的治疗传统上是手术治疗(引流)。我们报告了一项回顾性研究(1988年至1991年),介绍我们对11例儿童孤立性此类脓肿仅采用内科治疗的经验。7例脓肿在阑尾切除术后10天内被发现。超声检查7次将脓肿定位在右髂窝,4次定位在Douglas窝。4例脓肿直径大于5厘米。肠外抗生素治疗6次联合使用替卡西林和克拉维酸,5次联合使用哌拉西林、妥布霉素和甲硝唑。通过临床体征(发热、疼痛、肠梗阻)和超声检查评估药物疗效。1例患者在治疗第4天因并发肠梗阻而再次手术。其他10例患者在治疗第一周内临床体征消失。在第7天,肠外治疗改为口服抗生素治疗(甲硝唑7次,阿莫西林-克拉维酸3次),持续至超声检查未再发现脓肿(3周时5次,1个月时5次)。因此,在无并发肠梗阻的情况下,儿童孤立性阑尾切除术后脓肿的内科治疗似乎是合理的选择。

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