Arakaki M, Yamashita S, Mutaf M, Naito S, Fujii T
Department of Plastic and Reconstructive Surgery, Nagasaki University School of Medicine, Japan.
Cleft Palate Craniofac J. 1995 Jul;32(4):282-9. doi: 10.1597/1545-1569_1995_032_0282_osahtc_2.3.co_2.
We investigated how a new type of synthetic porous hydroxyapatite ceramic (HAP-TCP) acts when it is implanted in growing membranous bone. Seventy-six New Zealand White infant male rabbits (4-week-olds) were used. Rabbits received HAP-TCP block or silicone block implantation in their right nasal bone. The left nasal bone was used for a sham. Serial or cross-sectional examinations by morphometry, radiology, blood biochemistry, and histology were carried out. Both the HAP-TCP and silicone groups exhibited no systemic growth disturbance in terms of morphometry and blood biochemistry. Dual energy x-ray absorptiometry (DEXA) revealed, however, a decrease in the bone mineral content (BMC) of the right nasal bone in the silicone group. Histology revealed a superior affinity of HAP-TCP to bone tissue than that of silicone. When a HAP-TCP block was implanted under the periosteum it bonded directly to bone tissue. However, sinking of the implants into the bone tissue were noted both in the HAP-TCP and the silicone groups in longitudinal observation. These results suggest that although HAP-TCP has superior affinity to bone tissue, this by itself is not enough sufficient reason to believe that HAP-TCP can be effectively applied during the growth period.
我们研究了一种新型合成多孔羟基磷灰石陶瓷（HAP-TCP）植入生长中的膜性骨时的作用情况。使用了76只新西兰白色雄性幼兔（4周龄）。兔子在其右侧鼻骨接受HAP-TCP块或硅胶块植入。左侧鼻骨用作假手术对照。通过形态测量学、放射学、血液生物化学和组织学进行了系列或横断面检查。就形态测量学和血液生物化学而言，HAP-TCP组和硅胶组均未表现出全身性生长紊乱。然而，双能X线吸收法（DEXA）显示硅胶组右侧鼻骨的骨矿物质含量（BMC）有所下降。组织学显示HAP-TCP对骨组织的亲和力优于硅胶。当在骨膜下植入HAP-TCP块时，它直接与骨组织结合。然而，在纵向观察中，HAP-TCP组和硅胶组均出现植入物沉入骨组织的情况。这些结果表明，尽管HAP-TCP对骨组织具有优异的亲和力，但仅凭这一点并不足以认为HAP-TCP可在生长期间有效应用。
