Sauer H, Kinne R K, Wehner F
Max-Planck-Institut für molekulare Physiologie, Abteilung Epithelphysiologie, Dortmund, Germany.
Biochim Biophys Acta. 1995 Oct 4;1239(1):99-102. doi: 10.1016/0005-2736(95)00149-w.
In intracellular recordings with conventional microelectrodes on rat IMCD cells, we find that hypotonic stress depolarizes membrane voltage and decreases cell input resistance. Ion substitution experiments reveal that these effects are largely due to the activation of a prominent Cl- conductance. After block of this conductance with dideoxyforskolin a smaller concomitant increase in K+ conductance becomes detectable.
在使用传统微电极对大鼠内髓集合管（IMCD）细胞进行细胞内记录时，我们发现低渗应激会使膜电压去极化并降低细胞输入电阻。离子替代实验表明，这些效应主要是由于一种显著的氯离子电导被激活所致。在用双脱氧佛司可林阻断这种电导后，可检测到伴随出现较小的钾离子电导增加。
