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Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor.

作者信息

Mackiewicz A, Górny A, Laciak M, Malicki J, Murawa P, Nowak J, Wiznerowicz M, Hawley R G, Heinrich P C, Rose-John S

机构信息

Dept. of Cancer Immunology, University School of Medical Sciences at GreatPoland Cancer Center, Poznań.

出版信息

Hum Gene Ther. 1995 Jun;6(6):805-11. doi: 10.1089/hum.1995.6.6-805.

DOI:10.1089/hum.1995.6.6-805
PMID:7548280
Abstract
摘要

相似文献

1
Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor.人类黑色素瘤的基因治疗。用自体肿瘤细胞与分泌白细胞介素6和可溶性白细胞介素6受体的同种异体黑色素瘤细胞混合对患者进行免疫接种。
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Immunogene therapy of human melanoma. Phase I/II clinical trial.人类黑色素瘤的免疫基因治疗。I/II期临床试验。
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A pilot study of immunization with HLA-A2 matched allogeneic melanoma cells that secrete interleukin-2 in patients with metastatic melanoma.一项针对转移性黑色素瘤患者,使用分泌白细胞介素-2的HLA-A2匹配的同种异体黑色素瘤细胞进行免疫治疗的初步研究。
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Active immunization of metastatic melanoma patients with interleukin-4 transduced, allogeneic melanoma cells. A phase I-II study.用白细胞介素-4转导的同种异体黑色素瘤细胞对转移性黑色素瘤患者进行主动免疫。一项I-II期研究。
Hum Gene Ther. 1994 Aug;5(8):1059-64. doi: 10.1089/hum.1994.5.8-1059.
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Increased non-major histocompatibility complex-restricted lytic activity in melanoma patients vaccinated with cytokine gene-transfected autologous tumor cells.用细胞因子基因转染的自体肿瘤细胞接种的黑色素瘤患者中,非主要组织相容性复合体限制的溶解活性增加。
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Double-copy bicistronic retroviral vector platform for gene therapy and tissue engineering: application to melanoma vaccine development.用于基因治疗和组织工程的双拷贝双顺反子逆转录病毒载体平台:在黑色素瘤疫苗研发中的应用
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[Expression of cDNA for human interleukin-8 type one receptor in BALB 3T3 fibroblasts and characteristics of products of expression].[人白细胞介素-8 Ⅰ型受体cDNA在BALB 3T3成纤维细胞中的表达及表达产物特性]
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Vaccination of melanoma patients with interleukin 4 gene-transduced allogeneic melanoma cells.用白细胞介素4基因转导的同种异体黑色素瘤细胞对黑色素瘤患者进行疫苗接种。
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引用本文的文献

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Insights Into Dendritic Cells in Cancer Immunotherapy: From Bench to Clinical Applications.癌症免疫治疗中树突状细胞的见解:从实验台到临床应用
Front Cell Dev Biol. 2021 Jun 28;9:686544. doi: 10.3389/fcell.2021.686544. eCollection 2021.
2
Interleukin-6 gene ablation in a transgenic mouse model of malignant skin melanoma.恶性皮肤黑色素瘤转基因小鼠模型中的白细胞介素-6基因敲除
Am J Pathol. 2005 Mar;166(3):831-41. doi: 10.1016/S0002-9440(10)62304-8.
3
The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.
可溶性白细胞介素6(IL-6)受体在体内的功能:人可溶性IL-6受体转基因小鼠对IL-6的致敏作用以及IL-6血浆半衰期的延长。
J Exp Med. 1996 Apr 1;183(4):1399-406. doi: 10.1084/jem.183.4.1399.
4
Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.对人白细胞介素-6进行工程改造以获得生物活性大幅增强的变体。
EMBO J. 1996 Jun 3;15(11):2726-37.