人类黑色素瘤的基因治疗。用自体肿瘤细胞与分泌白细胞介素6和可溶性白细胞介素6受体的同种异体黑色素瘤细胞混合对患者进行免疫接种。 - Suppr

Suppr

超能文献

Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor.

作者信息

Mackiewicz A, Górny A, Laciak M, Malicki J, Murawa P, Nowak J, Wiznerowicz M, Hawley R G, Heinrich P C, Rose-John S

机构信息

Dept. of Cancer Immunology, University School of Medical Sciences at GreatPoland Cancer Center, Poznań.

出版信息

Hum Gene Ther. 1995 Jun;6(6):805-11. doi: 10.1089/hum.1995.6.6-805.

DOI:10.1089/hum.1995.6.6-805

PMID:7548280

Abstract

摘要

相似文献

Gene therapy of human melanoma. Immunization of patients with autologous tumor cells admixed with allogeneic melanoma cells secreting interleukin 6 and soluble interleukin 6 receptor.人类黑色素瘤的基因治疗。用自体肿瘤细胞与分泌白细胞介素6和可溶性白细胞介素6受体的同种异体黑色素瘤细胞混合对患者进行免疫接种。

Hum Gene Ther. 1995 Jun;6(6):805-11. doi: 10.1089/hum.1995.6.6-805.

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Immunogene therapy of human melanoma. Phase I/II clinical trial.人类黑色素瘤的免疫基因治疗。I/II期临床试验。

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A pilot study of immunization with HLA-A2 matched allogeneic melanoma cells that secrete interleukin-2 in patients with metastatic melanoma.一项针对转移性黑色素瘤患者，使用分泌白细胞介素-2的HLA-A2匹配的同种异体黑色素瘤细胞进行免疫治疗的初步研究。

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Increased non-major histocompatibility complex-restricted lytic activity in melanoma patients vaccinated with cytokine gene-transfected autologous tumor cells.用细胞因子基因转染的自体肿瘤细胞接种的黑色素瘤患者中，非主要组织相容性复合体限制的溶解活性增加。

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Phase I study to the immunotherapy of metastatic malignant melanoma by a cancer vaccine consisting of autologous cancer cells transfected with the human IL-2 gene.一项关于用人白细胞介素-2基因转染的自体癌细胞组成的癌症疫苗对转移性恶性黑色素瘤进行免疫治疗的I期研究。

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Double-copy bicistronic retroviral vector platform for gene therapy and tissue engineering: application to melanoma vaccine development.用于基因治疗和组织工程的双拷贝双顺反子逆转录病毒载体平台：在黑色素瘤疫苗研发中的应用

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[Expression of cDNA for human interleukin-8 type one receptor in BALB 3T3 fibroblasts and characteristics of products of expression].[人白细胞介素-8 Ⅰ型受体cDNA在BALB 3T3成纤维细胞中的表达及表达产物特性]

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Vaccination of melanoma patients with interleukin 4 gene-transduced allogeneic melanoma cells.用白细胞介素4基因转导的同种异体黑色素瘤细胞对黑色素瘤患者进行疫苗接种。

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Interleukin-6 gene ablation in a transgenic mouse model of malignant skin melanoma.恶性皮肤黑色素瘤转基因小鼠模型中的白细胞介素-6基因敲除

Am J Pathol. 2005 Mar;166(3):831-41. doi: 10.1016/S0002-9440(10)62304-8.

The function of the soluble interleukin 6 (IL-6) receptor in vivo: sensitization of human soluble IL-6 receptor transgenic mice towards IL-6 and prolongation of the plasma half-life of IL-6.可溶性白细胞介素6（IL-6）受体在体内的功能：人可溶性IL-6受体转基因小鼠对IL-6的致敏作用以及IL-6血浆半衰期的延长。

J Exp Med. 1996 Apr 1;183(4):1399-406. doi: 10.1084/jem.183.4.1399.

Engineering human interleukin-6 to obtain variants with strongly enhanced bioactivity.对人白细胞介素-6进行工程改造以获得生物活性大幅增强的变体。

EMBO J. 1996 Jun 3;15(11):2726-37.

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