乳铁蛋白与转铁蛋白之间的免疫交叉反应。

Immunological cross-reaction between lactoferrin and transferrin.

作者信息

Watanabe K, Yahikozawa S, Orino K, Yamamoto S

机构信息

Laboratory of Biochemistry, School of Veterinary Medicine and Animal Sciences, Kitasato University, Aomori, Japan.

出版信息

J Vet Med Sci. 1995 Jun;57(3):519-21. doi: 10.1292/jvms.57.519.

DOI:10.1292/jvms.57.519

PMID:7548410

Abstract

Hardly any or only a weak immunological cross-reaction was found between native lactoferrin (Lf) and transferrin (Tf). However, when these iron-binding proteins were denatured with sodium dodecyl sulfate and dithiothreitol, a definite immunological cross-reaction was detected between them. These results indicate that although Lf and Tf are immunologically quite different from each other in their native forms, they have the common antigenic determinant(s) in their unfolded forms.

摘要

天然乳铁蛋白（Lf）和转铁蛋白（Tf）之间几乎未发现或仅发现微弱的免疫交叉反应。然而，当这些铁结合蛋白用十二烷基硫酸钠和二硫苏糖醇变性后，它们之间检测到明确的免疫交叉反应。这些结果表明，尽管Lf和Tf在天然形式下免疫性差异很大，但它们在展开形式下具有共同的抗原决定簇。