Yamada N, Martin-Iverson M T, Daimon K, Tsujimoto T, Takahashi S
Department of Psychiatry, Shiga University of Medical Science.
Biol Psychiatry. 1995 Jun 15;37(12):866-73. doi: 10.1016/0006-3223(94)00221-N.
Light therapy (bright or dim light) was given at different times (morning or evening) to 27 unmedicated patients with nonseasonal depression (according to DSM-III-R criteria) and 16 normal volunteers. Circadian rhythms in body temperature were measured before and after light therapy. Bright light significantly improved clinical symptoms of depression, as measured by the Hamilton Rating Scale for Depression (HRSD), independent of the time of phototherapy. Dim light therapy had no effect on HRSD scores. Circadian rhythms of body temperatures in patients with affective disorder were more sensitive to the entraining effects of bright light than those of normal subjects, but these effects were not related to clinical improvement. Bright light exposure has an antidepressant effect on patients with nonseasonal depression, but the effect is unlikely to be mediated via the same circadian system that regulates body temperature.
对27名未接受药物治疗的非季节性抑郁症患者（根据DSM-III-R标准）和16名正常志愿者在不同时间（早晨或晚上）进行光疗法（强光或弱光）。在光疗前后测量体温的昼夜节律。通过汉密尔顿抑郁量表（HRSD）测量，强光显著改善了抑郁的临床症状，与光疗时间无关。弱光疗法对HRSD评分没有影响。情感障碍患者的体温昼夜节律比正常受试者对强光的同步化作用更敏感，但这些作用与临床改善无关。强光照射对非季节性抑郁症患者有抗抑郁作用，但这种作用不太可能通过调节体温的同一昼夜节律系统介导。
