Tzianabos A O, Kasper D L, Onderdonk A B
Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.
Clin Infect Dis. 1995 Jun;20 Suppl 2:S132-40. doi: 10.1093/clinids/20.supplement_2.s132.
The capsular polysaccharide complex (CPC) of Bacteroides fragilis exhibits unusual biological properties. This polysaccharide complex promotes the formation of intraabdominal abscesses and, when administered systemically, can prevent abscess induction in a rat model of intraabdominal sepsis. Each of these biological properties is mediated by a T cell-dependent immune mechanism. The CPC consists of two distinct polysaccharides, PS A and PS B, each with repeating units that have positively charged amino groups and negatively charge carboxyl or phosphate groups. Analysis of these polysaccharides as well as of other charged polysaccharides of bacterial origin, before and after chemical modification, revealed that the oppositely charged groups are required for promotion of intraabdominal abscesses as well as for the distinct properties associated with the B. fragilis CPC and delineate one mechanism by which these biological responses occur.
脆弱拟杆菌的荚膜多糖复合物（CPC）具有不同寻常的生物学特性。这种多糖复合物能促进腹腔内脓肿的形成，并且在全身给药时，可预防腹腔脓毒症大鼠模型中脓肿的诱发。这些生物学特性均由T细胞依赖性免疫机制介导。CPC由两种不同的多糖PS A和PS B组成，每种多糖都有带正电荷氨基的重复单元以及带负电荷羧基或磷酸基团的重复单元。对这些多糖以及化学修饰前后其他细菌来源的带电荷多糖进行分析，结果显示促进腹腔内脓肿形成以及与脆弱拟杆菌CPC相关的独特特性都需要相反电荷的基团，并阐明了这些生物学反应发生的一种机制。
