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[淀粉样变肠道假性梗阻作为IgA多发性骨髓瘤的初始表现]

[Amyloid intestinal pseudo-obstruction as initial manifestation of IgA multiple myeloma].

作者信息

Domingo-García P, Pardo-García J L, Martínez-Albaladejo M, Moreno-Requena J

机构信息

Servicio de Cirugía, Hospital Comarcal del Noroeste, Caravaca de la Cruz, Murcia.

出版信息

An Med Interna. 1995 Jun;12(6):283-5.

PMID:7548645
Abstract

Amyloidosis is a well known complication of Multiple Myeloma. Although involvement of the gastrointestinal tract is common in patients with Amyloid, severe symptoms are no frequent, nevertheless vascular deposits may produce gastrointestinal ischemia and bleeding and perforation. Injured mucosae of the intestinal well may produce malabsorption and the neuromuscular infiltration determine alterations of gastrointestinal motility. Although renal and cardiac disfunction is the most frequently cause of death in these patients, intestinal pseudo-obstruction bears a serious prognosis. We present a case of a patients who was operated because of a presumptive diagnosis of intestinal obstruction, which small bowel was infiltrated with Amyloid and which bone marrow demonstrated multiple myeloma.

摘要

淀粉样变性是多发性骨髓瘤一种广为人知的并发症。尽管胃肠道受累在淀粉样变性患者中很常见,但严重症状并不频发,不过血管沉积物可能导致胃肠道缺血、出血及穿孔。肠道黏膜损伤可能导致吸收不良,神经肌肉浸润会引起胃肠动力改变。虽然肾脏和心脏功能障碍是这些患者最常见的死亡原因,但肠道假性梗阻预后严重。我们报告一例患者,该患者因疑似肠梗阻接受手术,其小肠被淀粉样物质浸润,骨髓显示为多发性骨髓瘤。

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