Rao M S, Reddy J K
Department of Pathology, Northwestern University Medical School, Chicago, IL 60611-3008, USA.
Semin Cell Biol. 1995 Jun;6(3):151-6. doi: 10.1006/scel.1995.0021.
The differentiated state of specialized cells appears to be dependent on interactions between the extracellular microenvironment, cytoplasmic signals and DNA. Perturbations in these interactions lead to phenotypic alterations of the cell--referred to as transdifferentiation. Copper deficiency in rats leads to global acinar cell loss due to apoptosis possibly leading to perturbations in cell-cell interactions and the microenvironment. Acinar cell loss is associated with the proliferation of ductular epithelial and oval cells. Massive depletion of the acinar cell pool creates severe expansion pressure on oval and ductular cells to fill the vacuity. This probably causes a change in the commitment of these cells resulting in transdifferentiation into hepatocytes. Pancreatic hepatocytes exhibit all the morphological and functional properties of liver parenchymal cells.
特化细胞的分化状态似乎依赖于细胞外微环境、细胞质信号和DNA之间的相互作用。这些相互作用的扰动会导致细胞的表型改变——称为转分化。大鼠体内铜缺乏会导致腺泡细胞因凋亡而整体缺失，这可能会导致细胞间相互作用和微环境的扰动。腺泡细胞缺失与小胆管上皮细胞和卵圆细胞的增殖有关。腺泡细胞池的大量消耗对卵圆细胞和小胆管细胞造成了巨大的扩张压力，以填补空缺。这可能会导致这些细胞的分化发生变化，从而转分化为肝细胞。胰腺肝细胞表现出肝实质细胞的所有形态和功能特性。
