[Quantification of lymph node perfusion using color duplex ultrasonography].

PURPOSE

20 parameters were defined to differentiate benign from malignant lymphadenopathy using computer assisted analysis of the lymph node perfusion demonstrated by colour Doppler flow imaging.

MATERIAL AND METHODS

In 112 lymph nodes a computer assisted analysis of 10 consecutive colour Doppler flow sonograms was performed after digital data transfer to a work station. Planimetric results, the colour coded Doppler shift frequency, changes of the perfusion during the heart cycle and the perfusion in the adjacent tissue were analysed using 20 parameters.

RESULTS

Discriminant analysis resulted in 7 parameters which reclassified correctly 82% of the lymph nodes (sensitivity 84%, specificity 80%). 72% of the lymph nodes could be classified in the three groups reactive lymphadenopathy, lymph node metastasis and malignant lymphoma.

CONCLUSIONS

Clinically known subjective signs of malignancy (increased size, low echogenicity, alterations of the perfusion) can be analysed quantitatively to differentiate benign from malignant lymphadenopathy.