Toyoshima S, Watanabe F, Saido H, Miyatake K, Nakano Y
Department of Applied Biological Chemistry, University of Osaka Prefecture, Japan.
Biosci Biotechnol Biochem. 1995 Aug;59(8):1598-9. doi: 10.1271/bbb.59.1598.
Ketone bodies were assayed in the urine of ten-week-old vitamin B12-deficient rats by a high-performance liquid chromatography. The urinary excretion of ketone bodies (352.5 +/- 68.3 mumol/day) as well as of methylmalonic acid was increased significantly by dietary vitamin B12 deficiency.
通过高效液相色谱法对10周龄维生素B12缺乏大鼠的尿液中的酮体进行了测定。饮食中维生素B12缺乏会使酮体（352.5±68.3微摩尔/天）以及甲基丙二酸的尿排泄量显著增加。
