Eiring P, Manncke B, Gerbracht K, Werner H
Department of Medical Microbiology, University of Tübingen, Germany.
Zentralbl Bakteriol. 1995 Apr;282(3):279-86. doi: 10.1016/s0934-8840(11)80128-3.
The laminin binding properties of eight species of the genus Bacteroides were examined using latex particle agglutination assay. B. fragilis was found to bind strongly to laminin, whereas all other species tested showed no or only weak laminin adherence. The pronounced differences in laminin binding activity between B. fragilis on the one side and B. thetaiotaomicron and B. ovatus on the other were determined to be statistically significant (p < 0.001 and p < 0.01, respectively). With regard to the relevance of laminin adherence for bacterial pathogenicity and invasiveness, our results give a possible explanation for the well-known finding that B. fragilis is the most frequently isolated pathogen in anaerobic bacteremia.
使用乳胶颗粒凝集试验检测了8种拟杆菌属细菌与层粘连蛋白的结合特性。结果发现脆弱拟杆菌与层粘连蛋白有强烈结合，而其他所有受试菌种均未显示或仅显示出较弱的层粘连蛋白黏附。脆弱拟杆菌与多形拟杆菌及卵形拟杆菌之间在层粘连蛋白结合活性上的显著差异经测定具有统计学意义（分别为p < 0.001和p < 0.01）。关于层粘连蛋白黏附与细菌致病性和侵袭性的相关性，我们的结果为一个众所周知的发现提供了一种可能的解释，即脆弱拟杆菌是厌氧菌血症中最常分离出的病原体。
