Yanagawa H, Yashiro M, Nakamura Y, Sakata K, Kawasaki T
Department of Public Health, Jichi Medical School, Tochigi-ken, Japan.
Acta Paediatr. 1995 Jul;84(7):765-8. doi: 10.1111/j.1651-2227.1995.tb13752.x.
The administration of i.v. gamma globulin (IVGG) for Kawasaki disease was investigated throughout Japan in 1993 by obtaining information from the pediatric departments of 2652 hospitals with more than 100 beds. A total of 1826 hospitals (68.9%) responded, reporting on 11,221 patients who were diagnosed during the survey period from January 1991 to December 1992. There were 8958 patients (79.8%) who received IVGG treatment. The most common treatment modality was 200 mg/kg (29.6%), followed by 400 mg/kg (18.7%) and 300 mg/kg (12.9%), all for 5 days. The distributions of total dose were: 1000 mg/kg or less, 45.7%; 1001-1500 mg/kg, 27.3%; and over 1500 mg/kg, 23.8%. For all patients to whom IVGG was administered, treatment was started in 53.8% by day 5 of illness and in 86.1% by day 7. The proportion of those with cardiac sequelae was higher in patients who were treated with IVGG, possibly due to the fact that those who were more severely affected were more likely to be treated with IVGG.
1993年，通过向2652家拥有100张以上床位医院的儿科部门收集信息，对日本全国范围内静脉注射丙种球蛋白（IVGG）治疗川崎病的情况进行了调查。共有1826家医院（68.9%）做出回应，报告了在1991年1月至1992年12月调查期间确诊的11221例患者。其中8958例患者（79.8%）接受了IVGG治疗。最常用的治疗方式是200mg/kg（29.6%），其次是400mg/kg（18.7%）和300mg/kg（12.9%），均持续5天。总剂量的分布情况为：1000mg/kg及以下，占45.7%；1001 - 1500mg/kg，占27.3%；超过1500mg/kg，占23.8%。在所有接受IVGG治疗的患者中，53.8%在发病第5天开始治疗，86.1%在发病第7天开始治疗。接受IVGG治疗的患者出现心脏后遗症的比例较高，这可能是因为病情较重的患者更有可能接受IVGG治疗。
